
Mission District Holidays
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to AU$2,500 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Mission District Holiday
Experience all the wonderful things this neighbourhood has to offer with a tailor-made Mission District holiday package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District holiday now.
Our guide on where to stay in Mission District

Fisherman's Wharf
This waterfront location is steeped in history dating back to the days of the gold rush. Today, visitors come here for its vibrant atmosphere and great food.
Our pick of the best Mission District Hotel Deals

Hotel Riu Plaza Fisherman's Wharf
"Clean room, breakfast"
Reviewed on 29 June 2026

Handlery Union Square Hotel
"Clean room, amazing friendly staff, nice amenities, beautiful view from our balcony! 10/10 stay"
Reviewed on 29 June 2026

Hyatt Regency San Francisco
"Room was very clean"
Reviewed on 29 June 2026
Frequently asked questions
Stay near popular Mission District attractions
Activities

Golden Gate Bay Cruise - Sail Around Alcatraz! (1-hour)

Alcatraz Visit with Night Option and SF Bay Cruise


















